日本研究人员在最新出版的《细胞 —干细胞》（ Cell Stem Cell）杂志上发表报告说，他们发现了导致急性 白血病复发的一个基因，如果能找到抑制该基因发挥作用的方法，就有可能防止急性 白血病的复发。

　　急性 白血病患者中有 70%到 80%的人都会复发。其原因是数量极少的白血病干细胞反复分裂，使白血病细胞大量增殖。抗癌药物虽然能够杀灭白血病细胞，但难以杀灭其中的白血病干细胞，造成急性白血病屡治屡发。东京大学教授黑川峰夫等人注意到，急性白血病复发患者体内的基因 “Evi－ 1”在造血干细胞中非常活跃，他们推测这一基因可能同样作用于白血病干细胞，使其不断分裂，导致白血病细胞大量增殖。

　　研究小组从患白血病的实验鼠体内取出白血病细胞，去除了 “Evi－ 1”基因后再移植到 10只健康实验鼠体内。研究小组还给另外 10只健康实验鼠完整移植了白血病细胞（含 “Evi－ 1”）。结果发现，前一组实验鼠比后一组实验鼠平均晚发病一个月；而在杀灭两组实验鼠体内的白血病细胞后，前一组实验鼠没有复发急性白血病，后一组却再次发病。（ Bioon.com）

　　研究人员认为，对照实验已经说明， “Evi－ 1”对急性白血病的发作和复发有推动作用，而这与它作用于白血病干细胞有直接关系。（ 生物谷Bioon.com）

生物谷 推荐原始出处：

Cell Stem Cell ， Vol 3, 207-220, 07 August 2008， usumu Goyama, Mineo Kurokawa

Evi-1 Is a Critical Regulator for Hematopoietic Stem Cells and Transformed Leukemic Cells

Susumu Goyama,¹ Go Yamamoto,¹ Munetake Shimabe,¹ Tomohiko Sato,¹ Motoshi Ichikawa,¹ Seishi Ogawa,¹,²,³ Shigeru Chiba,¹,² and Mineo Kurokawa¹,

¹ Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
² Department of Cell Therapy and Transplantation Medicine, Graduate School of Medicine, University of Tokyo, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
³ Department of Regeneration Medicine for Hematopoiesis, Graduate School of Medicine, University of Tokyo, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Corresponding author
Mineo Kurokawa
kurokawa-tky@umin.ac.jp

Summary

Evi-1 has been recognized as one of the dominant oncogenes associated with murine and human myeloid leukemia. Here, we show that hematopoietic stem cells (HSCs) inEvi-1-deficient embryos are severely reduced in number with defective proliferative and repopulating capacity. Selective ablation of Evi -1 in Tie2⁺ cells mimics Evi-1 deficiency, suggesting that Evi-1 function is required in Tie2⁺ hematopoietic stem/progenitors. Conditional deletion of Evi -1 in the adult hematopoietic system revealed thatEvi-1-deficient bone marrow HSCs cannot maintain hematopoiesis and lose their repopulating ability. In contrast, Evi-1 is dispensable for blood cell lineage commitment.Evi-1^{+/ −}